According to the World Health Organization, 300 million people around the world suffer from depression. 17.3 million adults in the United States equaling 7.1 percent of all adults in the country have experienced a major depressive episode in the past year. 11 million US adults experienced an episode that resulted in severe impairments in the past year. Depression can begin at any age and it can affect people of all races and across all socioeconomic statuses. Depression often interferes with work, school and relationships. Depression is the leading cause of disability in the United States among ages 15 to 44. Suicide is the second leading cause of death for ages 15 to 44. Over 47000 Americans die by suicide each year. 2/3rd of people with depression do not actually seek nor receive proper treatment. The proven treatments of depression include psychological treatments, medications, and brain stimulation therapies. Adequate treatment is difficult to achieve with standard therapies due to lack of efficacy or intolerable side effects. The likelihood of achieving remission is limited and declines with each subsequent medication treatment. Patients tend to discontinue treatments if they do not benefit from current treatments. Patients who do not benefit from medications may need a different approach to achieve remission.